Research & Resources
Peer-Reviewed Literature, Gathered for Patients
Reading the science is part of making an informed decision. Below is a library of published research indexed on PubMed, organized by topic, so you can review the evidence — including its limitations — before any conversation about care.
How to use this page
Education First, Conclusions Later
These citations are provided for educational purposes only. They are not an endorsement of any specific product or protocol, and they are not evidence that a therapy is right for you. Research in regenerative medicine is ongoing, findings sometimes conflict, and many approaches remain investigational. We encourage patients to read broadly, note the limitations authors describe, and bring questions to their physician.
Reading the research
How to Interpret These Research Links
Published studies can feel technical, but a few simple habits help you read them with confidence. As you explore the links below, keep these points in mind.
- Check the study typeA randomized controlled trial or a systematic review generally carries more weight than a single case report or an animal study. Note whether the findings come from human patients and how many were included.
- Look at the population studiedResults describe a specific group under specific conditions. A study of young athletes with acute injuries may not apply to older adults with long-standing arthritis, and vice versa.
- Read the limitationsAuthors openly describe the shortcomings of their work — small samples, short follow-up, lack of a comparison group. These limitations are part of honest science and matter for how much weight a finding deserves.
- Watch for conflicts of interestCheck whether the study was funded by a party with a commercial interest in the result. Funding does not invalidate a study, but it is worth knowing as you weigh the conclusions.
- One study is rarely conclusiveA single paper is a data point, not a verdict. Patterns across many studies — and the direction of the evidence over time — are more meaningful than any individual result.
Foundations
Understanding Regenerative Medicine
Background reading on what regenerative medicine is, how the field developed, and where the science currently stands.
- Regenerative medicine: current therapies and future directionsAn overview of how cell- and tissue-based approaches are being studied across medicine, and the translational hurdles that remain.View on PubMed
- Mesenchymal stem cells: biology and clinical applicationA review of mesenchymal stromal cell characteristics, signaling behavior, and the rationale behind their study in musculoskeletal conditions.View on PubMed
- PubMed search: regenerative medicine and orthopaedicsA live PubMed query returning current indexed literature at the intersection of regenerative approaches and orthopaedic care.View on PubMed
- Orthobiologics: a review of clinical evidenceExamines the biologic products used in orthopaedics, how they are prepared, and how consistently outcomes have been reported.View on PubMed
Knee & Osteoarthritis
Knee Pain and Arthritis Research
Studies examining non-surgical and biologic approaches to knee osteoarthritis, one of the most frequently researched areas in this field.
- Platelet-rich plasma versus hyaluronic acid in knee osteoarthritisA comparative analysis of two widely studied injection approaches, including reported pain and function measures over time.View on PubMed
- Mesenchymal stromal cell injection for knee osteoarthritisReviews clinical trials of cell-based injection in knee osteoarthritis, with attention to dosing variability and study quality.View on PubMed
- Bone marrow aspirate concentrate in cartilage and joint careAssesses reported outcomes and safety signals for bone marrow derived preparations used in joint and cartilage applications.View on PubMed
- PubMed search: knee osteoarthritis and platelet-rich plasmaA live PubMed query for the ongoing body of literature on PRP and knee osteoarthritis, including newer trials and reviews.View on PubMed
Tendon & Soft Tissue
Soft Tissue, Tendon, and Sports Injury
Literature relevant to tendon irritation, ligament injury, and the recovery questions active patients most often raise.
- Platelet-rich plasma in tendinopathy: mechanisms and outcomesDiscusses the proposed biologic mechanisms in tendon healing alongside the mixed clinical results reported to date.View on PubMed
- Rotator cuff repair augmented with biologic preparationsLooks at whether biologic augmentation changes healing rates and functional scores after rotator cuff procedures.View on PubMed
- Biologic approaches in sports medicineA sports medicine perspective on where biologic treatments are being studied, and how return-to-activity is measured.View on PubMed
- PubMed search: tendinopathy and biologic therapyA live PubMed query covering current studies on tendon disorders and biologic treatment approaches.View on PubMed
Safety & Regulation
Safety, Candidacy, and Regulatory Context
Reading that addresses risk, patient selection, marketing claims, and the regulatory framework surrounding cell-based therapies.
- Adverse events reported in stem cell interventionsSummarizes documented complications and reporting gaps in published cell-based intervention studies.View on PubMed
- Direct-to-consumer marketing of stem cell interventionsAnalyzes how unproven therapies are advertised to patients and why claims often outpace the underlying evidence.View on PubMed
- Patient selection in orthobiologic treatmentDiscusses why candidacy, disease stage, and expectations meaningfully affect reported results.View on PubMed
- PubMed search: stem cell therapy safetyA live PubMed query for safety-focused literature on cell-based therapies across specialties.View on PubMed
Research Is a Starting Point, Not a Diagnosis
Published studies describe groups of patients under specific conditions. They cannot tell you whether an approach is appropriate for your body, your history, or your goals. That determination requires an in-person evaluation with a qualified physician.
Educational Disclaimer
The research links on this page are provided for educational purposes only. They are not medical advice, not a recommendation of any therapy, and not a substitute for an individualized clinical evaluation. TrueArc Health does not control the content of third-party sites and is not responsible for the information they contain. A consultation with a qualified medical provider is required to determine whether any care option may be appropriate for your individual situation.